Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785415 | 1.00 | SPR (0.41) | SPRTRPM8DRD3KMT2AACHE | |
| SCHEMBL803576 | 0.88 | LMNA (0.40) | SPRTRPM8DRD3KMT2AACHE | |
| SCHEMBL484622 | 0.87 | HPGD (0.49) | SPRTRPM8DRD3ALDH1A1XBP1 | |
| SCHEMBL785069 | 0.87 | HPGD (0.49) | SPRTRPM8DRD3ALDH1A1XBP1 | |
| SCHEMBL784544 | 0.85 | TRPM8 (0.43) | TRPM8DRD3KMT2AACHE | |
| SCHEMBL785923 | 0.85 | TRPM8 (0.43) | TRPM8DRD3KMT2AACHE | |
| SCHEMBL784638 | 0.85 | DRD3 (0.41) | TRPM8DRD3KMT2AACHEDRD2 | |
| SCHEMBL784639 | 0.85 | DRD3 (0.41) | TRPM8DRD3KMT2AACHEDRD2 | |
| SCHEMBL803262 | 0.81 | TRPM8 (0.40) | SPRTRPM8DRD3KMT2AACHE | |
| SCHEMBL785540 | 0.81 | TRPM8 (0.40) | SPRTRPM8DRD3KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | SPR 1860/4885TRPM8 180/4885DRD3 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.