Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785382 | 1.00 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KCNH2OPRK1 | |
| SCHEMBL785646 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2OPRK1 | |
| SCHEMBL785647 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2OPRK1 | |
| SCHEMBL785167 | 0.89 | TP53 (0.43) | SLC6A2SLC6A4SLC6A3TRPM8DRD3 | |
| SCHEMBL785978 | 0.89 | TP53 (0.43) | SLC6A2SLC6A4SLC6A3TRPM8DRD3 | |
| SCHEMBL785967 | 0.85 | TRPM8 (0.47) | TRPM8DRD3HPGDTSHR | |
| SCHEMBL785968 | 0.85 | TRPM8 (0.47) | TRPM8DRD3HPGDTSHR | |
| SCHEMBL2822146 | 0.84 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3TRPM8DRD3 | |
| SCHEMBL484953 | 0.84 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3TRPM8DRD3 | |
| SCHEMBL484622 | 0.83 | HPGD (0.49) | TRPM8DRD3HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | SLC6A2 1966/4885SLC6A4 1682/4885SLC6A3 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.