SCHEMBL7854334

SCHEMBL7854334

C=CCc1cc2c(c(CC=C)c1O)CCC(=O)N2Cc1ccc(C(=O)O)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
HDAC1 Q13547 5/20 0.39
HDAC8 Q9BY41 5/20 0.39
HDAC6 Q9UBN7 5/20 0.39
ALDH1A1 P00352 4/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 2/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
THRB P10828 1/20 0.38
HTT P42858 1/20 0.38
RECQL P46063 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ENPP2 Q13822 1/20 0.37
EGLN1 Q9GZT9 1/20 0.37
HPGD P15428 2/20 0.35
KDM4E B2RXH2 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7844774 0.99 PTGS1 (0.38) PTGS1PTGS2HDAC1HDAC8HDAC6
SCHEMBL7855653 0.93 POLB (0.36) HDAC1HDAC8HDAC6ALDH1A1MEN1
SCHEMBL7844769 0.90 HDAC1 (0.37) HDAC1HDAC8HDAC6ALDH1A1POLB
SCHEMBL7856424 0.88 ALDH1A1 (0.40) HDAC1HDAC8HDAC6ALDH1A1MEN1
SCHEMBL7854244 0.85 MAPT (0.41) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL7852043 0.82 MEN1 (0.35) ALDH1A1MEN1KMT2AGAAHTT
SCHEMBL7855486 0.81 MEN1 (0.34) ALDH1A1MEN1KMT2AGAAHTT
SCHEMBL7855481 0.81 MEN1 (0.34) ALDH1A1MEN1KMT2AGAAHTT
SCHEMBL7852202 0.78 KDM4E (0.31) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL7845505 0.78 KDM4E (0.32) GAAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0719258-B1 CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS OTSUKA PHARMA CO LTD (JP) 2001-10-31 EP disclosed
US-5786367-A OXYGEN SCAVENGERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-07-28 US disclosed
EP-0719258-A1 CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-07-03 EP disclosed
WO-1996002508-A1 CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-02-01 WO disclosed