Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | FABP1 | P07148 | 1/20 | 0.32 |
| ▸ | FABP6 | P51161 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021148 | 0.79 | CYP2D6 (0.46) | CYP2D6FDPSCXCR4FABP1FABP6 | |
| SCHEMBL5099502 | 0.77 | CDK2 (0.44) | CDK1CDK4CCNB1CCNA2CCND1 | |
| SCHEMBL7854740 | 0.72 | RAB9A (0.40) | CYP2D6FDPSCXCR4MEN1ALDH1A1 | |
| SCHEMBL7853925 | 0.71 | PIK3CA (0.41) | FDPSMEN1ALDH1A1KMT2A | |
| SCHEMBL7022559 | 0.70 | CYP2D6 (0.36) | CYP2D6FDPSCDK1CDK4CCNB1 | |
| SCHEMBL7851108 | 0.68 | MEN1 (0.36) | CYP2D6FDPSCDK2FABP1FABP6 | |
| SCHEMBL3758388 | 0.66 | CYP2D6 (0.66) | CYP2D6FDPSCXCR4FABP1FABP6 | |
| SCHEMBL14198659 | 0.65 | CYP2D6 (0.56) | CYP2D6FDPSCXCR4FABP1FABP6 | |
| SCHEMBL1831588 | 0.65 | CYP2D6 (0.56) | CYP2D6FDPSCXCR4FABP1FABP6 | |
| SCHEMBL7015556 | 0.61 | FABP1 (0.41) | CYP2D6FDPSCXCR4FABP1FABP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |