Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955753 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1MAPTUSP2 | |
| SCHEMBL7838763 | 0.90 | MMP3 (0.36) | KMT2AMEN1MAPTMMP1MMP3 | |
| SCHEMBL7838759 | 0.90 | MMP3 (0.36) | KMT2AMEN1MAPTMMP1MMP3 | |
| SCHEMBL7836618 | 0.89 | MMP1 (0.36) | KMT2AMEN1MAPTMMP1MMP3 | |
| SCHEMBL7946538 | 0.89 | MMP1 (0.41) | ALDH1A1KMT2AMEN1MAPTUSP2 | |
| SCHEMBL7946539 | 0.89 | MMP1 (0.41) | ALDH1A1KMT2AMEN1MAPTUSP2 | |
| SCHEMBL7850472 | 0.88 | MMP3 (0.37) | KMT2AMEN1MAPTMMP1MMP3 | |
| SCHEMBL7838766 | 0.88 | MMP3 (0.37) | KMT2AMEN1MAPTMMP1MMP3 | |
| SCHEMBL7955182 | 0.87 | MEN1 (0.39) | ALDH1A1KMT2AMEN1MAPTMMP1 | |
| SCHEMBL7856205 | 0.82 | ALDH1A1 (0.38) | ALDH1A1KMT2AMEN1MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |