SCHEMBL7856324

SCHEMBL7856324

O=[C]c1c(O)c2ccccc2n1O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.38
ERCC1 P07992 1/20 0.37
FEN1 P39748 1/20 0.37
ERCC4 Q92889 1/20 0.37
ALDH1A1 P00352 7/20 0.37
KMT2A Q03164 3/20 0.37
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HPGD P15428 4/20 0.36
HTT P42858 3/20 0.36
CYP2C19 P33261 3/20 0.36
GAA P10253 2/20 0.36
HSD17B10 Q99714 2/20 0.36
GLA P06280 2/20 0.36
RCE1 Q9Y256 1/20 0.36
POLB P06746 3/20 0.34
RXFP1 Q9HBX9 2/20 0.34
BACE1 P56817 2/20 0.33
MAPT P10636 2/20 0.33
PRNP P04156 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1490129 0.73 KDM4E (0.39) KDM4EERCC1FEN1ERCC4ALDH1A1
SCHEMBL31623977 0.73 KDM4E (0.39) KDM4EERCC1FEN1ERCC4ALDH1A1
SCHEMBL148215 0.69 KMT2A (0.42) KDM4EALDH1A1KMT2ALMNASMN1; SMN2
SCHEMBL1408789 0.69 GPR3 (0.52) KDM4EERCC1FEN1ERCC4ALDH1A1
Methane SCHEMBL151037 0.67 BACE1 (0.50) KDM4EERCC1FEN1ERCC4ALDH1A1
SCHEMBL7896123 0.66 ALDH1A1 (0.54) KDM4EERCC1FEN1ERCC4ALDH1A1
Ethane SCHEMBL28032544 0.65 GPR3 (0.55) KDM4EERCC1FEN1ERCC4ALDH1A1
SCHEMBL8112946 0.65 KDM4E (0.48) KDM4EALDH1A1KMT2ALMNASMN1; SMN2
SCHEMBL27533951 0.63 ERCC1 (0.46) KDM4EERCC1FEN1ERCC4ALDH1A1
SCHEMBL7898975 0.63 KDM4E (0.60) KDM4EERCC1FEN1ERCC4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2935587-B1 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE LVMH RECH (FR) 2018-03-14 EP disclosed
US-9732348-B2 Aptamers inhibiting the enzymatic activity of tyrosinase L V M H Recherché (FR) 2017-08-15 US disclosed
US-20150329863-A1 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2015-11-19 US disclosed
EP-2935587-A1 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE LVMH RECHERCHE (FR) 2015-10-28 EP disclosed
WO-2014102213-A1 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE L V M H RECHERCHE (FR) 2014-07-03 WO disclosed
EP-0709373-B1 PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU (JP) 2001-10-17 EP disclosed
US-5756763-A ENZYME INHIBITOR ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1998-05-26 US disclosed
EP-0709373-A1 NOVEL PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1996-05-01 EP disclosed