Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP5 | P45974 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060636 | 0.95 | MMP1 (0.67) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL26135918 | 0.87 | MMP1 (0.76) | MMP1PTPN1GSK3BHDAC1HDAC8 | |
| SCHEMBL10884944 | 0.85 | SMN1; SMN2 (0.88) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL2743312 | 0.84 | HDAC1 (0.62) | RAB9AMMP1PTPN1GSK3BKMT2A | |
| SCHEMBL5849402 | 0.84 | HDAC1 (0.67) | LMNARAB9AMMP1PTPN1GSK3B | |
| SCHEMBL6931300 | 0.83 | NPC1 (0.65) | RAB9AHIF1AMMP1PTPN1HDAC8 | |
| SCHEMBL31279403 | 0.83 | HPGD (0.64) | SMN1; SMN2MMP1PTPN1GSK3BHDAC1 | |
| SCHEMBL7864409 | 0.83 | RAB9A (0.66) | SMN1; SMN2FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL3381534 | 0.83 | HDAC1 (0.69) | LMNARAB9AMMP1PTPN1GSK3B | |
| SCHEMBL5849457 | 0.83 | HDAC1 (0.69) | LMNARAB9AMMP1PTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307089-B2 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY | 2001-10-23 | — | — | US | disclosed |
| US-6239288-B1 | RHEUMATIC DISEASES | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| US-20010000513-A1 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY | 2001-04-26 | — | — | US | disclosed |
| EP-0927156-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998009940-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000513-A1 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | MMP26, MMP1, MMP9 | SMN1; SMN2 1912/4885FFAR1 515/4885LMNA 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.