Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | MMP3 | P08254 | 9/20 | 0.50 |
| ▸ | MMP1 | P03956 | 8/20 | 0.50 |
| ▸ | MMP2 | P08253 | 8/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424724 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6823664 | 0.80 | MMP3 (0.62) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6819981 | 0.75 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6825876 | 0.72 | MMP2 (0.60) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6422449 | 0.71 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6822907 | 0.71 | HDAC1 (0.52) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6422312 | 0.70 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL6823533 | 0.69 | SIRT5 (0.56) | PDE4APDE4BPDE4CPDE4DMMP3 | |
| SCHEMBL8891569 | 0.69 | KDM4E (0.52) | MTNR1AMTNR1BALOX5CSNK2A2CSNK2A1 | |
| SCHEMBL6424681 | 0.68 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306873-B1 | Substituted β-thiocarboxylic acids | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-10-23 | — | — | US | disclosed |