Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729956 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1PDE3A | |
| SCHEMBL5730259 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1PDE3A | |
| SCHEMBL7846360 | 0.71 | PPARD (0.33) | ALDH1A1 | |
| SCHEMBL5730289 | 0.69 | MEN1 (0.43) | PTGS2PTGS1PDE3A | |
| SCHEMBL5729672 | 0.69 | PTGS2 (0.70) | PTGS2PTGS1PDE3A | |
| SCHEMBL3925069 | 0.69 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL29652045 | 0.68 | FDPS (0.71) | ALDH1A1 | |
| SCHEMBL1396839 | 0.68 | FDPS (0.71) | ALDH1A1 | |
| SCHEMBL1748511 | 0.68 | ALDH1A1 (0.66) | ALDH1A1 | |
| SCHEMBL6772444 | 0.68 | TRIM24 (0.47) | PTGS2PTGS1PDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102755-A1 | SUBSTITUTED ISOXAZOLE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008001-A1 | SUBSTITUTED ISOXAZOLE AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |