Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.65 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.65 |
| ▸ | CDC25B | P30305 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GALK1 | P51570 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14133550 | 0.93 | CDC25B (0.60) | P2RX3PSDCDC25BMEN1KMT2A | |
| SCHEMBL3171373 | 0.87 | PTPN1 (0.76) | P2RX3PSDCDC25BMEN1KMT2A | |
| SCHEMBL3171364 | 0.87 | PTPN1 (0.76) | P2RX3PSDCDC25BMEN1KMT2A | |
| SCHEMBL3171382 | 0.87 | PTPN1 (0.76) | P2RX3PSDCDC25BMEN1KMT2A | |
| SCHEMBL7852509 | 0.86 | MEN1 (0.75) | MEN1KMT2APOLBDNMT1MAPT | |
| SCHEMBL7862701 | 0.85 | MEN1 (0.69) | MEN1KMT2APOLBDNMT1MAPT | |
| SCHEMBL7862713 | 0.83 | CDC25B (0.69) | P2RX3PSDCDC25BMEN1KMT2A | |
| SCHEMBL7859604 | 0.82 | PTPN1 (0.72) | MEN1KMT2APOLBDNMT1MAPT | |
| SCHEMBL14133153 | 0.82 | PTPN1 (0.61) | MEN1KMT2APOLBDNMT1MAPT | |
| SCHEMBL17298736 | 0.79 | P2RX3 (1.00) | P2RX3PSDCDC25BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | P2RX3 2768/4885PSD 2034/4885CDC25B 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.