Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | IDE | P14735 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.51 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PRF1 | P14222 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902258 | 0.86 | KMT2A (0.57) | MEN1KMT2APOLBGFERNSD2 | |
| SCHEMBL1902256 | 0.86 | KMT2A (0.57) | MEN1KMT2APOLBGFERNSD2 | |
| SCHEMBL1902254 | 0.86 | KMT2A (0.57) | MEN1KMT2APOLBGFERNSD2 | |
| SCHEMBL7859584 | 0.84 | TDP1 (0.54) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL23578840 | 0.84 | TDP1 (0.54) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL15761663 | 0.80 | MEN1 (0.59) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL13726902 | 0.79 | PDE4B (0.58) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL13726901 | 0.79 | PDE4B (0.58) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL7859591 | 0.79 | MEN1 (0.50) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL16210973 | 0.77 | PDE4B (0.62) | MEN1KMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | MEN1 1839/4885KMT2A 3345/4885ALDH1A1 4227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.