Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.68 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | EIF4E | P06730 | 1/20 | 0.55 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901622 | 0.88 | MAPT (0.63) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL3903530 | 0.88 | MAPT (0.63) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL7858419 | 0.87 | POLB (0.78) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL3897031 | 0.87 | POLB (0.78) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL3897032 | 0.87 | POLB (0.78) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL3907019 | 0.87 | POLB (0.61) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL3907023 | 0.87 | POLB (0.61) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL7852520 | 0.85 | MAPT (0.75) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL20714251 | 0.84 | ALDH1A1 (0.80) | ALDH1A1POLBMAPTLMNARAB9A | |
| SCHEMBL3890816 | 0.83 | MAP3K5 (0.67) | ALDH1A1POLBMAPTLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | ALDH1A1 4227/4885POLB 3712/4885MAPT 2957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.