Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987215 | 0.85 | MAPT (0.48) | MAOBGAAMAPTTSHRMAPK1 | |
| SCHEMBL3988125 | 0.80 | MAPK8 (0.45) | MAPTTSHRHTTSMN1; SMN2LMNA | |
| SCHEMBL7859648 | 0.78 | SLC6A4 (0.43) | MAOBMAPTTSHRHTR2ASLC6A4 | |
| SCHEMBL3987501 | 0.78 | ALDH1A1 (0.40) | GAAMAPK1HTTHTR2ASLC6A4 | |
| SCHEMBL3985498 | 0.78 | TTR (0.40) | GAAMAPK1HTTHTR2ASLC6A4 | |
| SCHEMBL3038603 | 0.75 | GAA (0.69) | MAOBCYP19A1GAAMAPTTSHR | |
| SCHEMBL8892263 | 0.74 | THRB (0.43) | MAPTHTR2ASLC6A4KCNH2MEN1 | |
| SCHEMBL3991197 | 0.74 | MAPT (0.44) | CYP19A1MAPTHTTSMN1; SMN2LMNA | |
| SCHEMBL9538832 | 0.73 | GAA (0.43) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL18998446 | 0.71 | THRB (0.40) | MAPTHTR2ASLC6A4KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877816-B2 | 4-(or 5-) substituted catechol derivatives | DECODE GENETICS EHF (IS) | 2014-11-04 | — | — | US | disclosed |
| US-8877816-B2 | 4-(or 5-) substituted catechol derivatives | DECODE GENETICS EHF (IS) | 2014-11-04 | — | — | US | disclosed |
| WO-2009067597-A1 | 4- (OR 5-) SUBSTITUTED CATECHOL DERIVATIVES | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| US-20090131530-A1 | 4- (OR 5-) SUBSTITUTED CATECHOL DERIVATIVES | DECODE GENETICS EHF (IS) | 2009-05-21 | — | — | US | disclosed |
| US-20090131530-A1 | 4- (OR 5-) SUBSTITUTED CATECHOL DERIVATIVES | DECODE GENETICS EHF (IS) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131530-A1 | 4- (OR 5-) SUBSTITUTED CATECHOL DERIVATIVES | PDE4A, PDE4B, PDE3B | MAOB 33/4885CYP19A1 693/4885GAA 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.