Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788490 | 0.86 | GAA (0.40) | GAAHTTALDH1A1MAPTTSHR | |
| SCHEMBL3038603 | 0.79 | GAA (0.69) | GAAHTTALDH1A1MAPTTSHR | |
| SCHEMBL15906106 | 0.76 | SMN1; SMN2 (0.41) | GAAMAPTTSHRMAPK1LTA4H | |
| SCHEMBL9535895 | 0.75 | CNR1 (0.41) | GAAALDH1A1SMN1; SMN2GPR55 | |
| SCHEMBL9538789 | 0.75 | ALDH1A1 (0.46) | GAAALDH1A1CA2KMT2APOLB | |
| SCHEMBL3153666 | 0.75 | KMT2A (0.56) | GAAALDH1A1MAPTMAPK1LTA4H | |
| SCHEMBL7859778 | 0.73 | MAOB (0.42) | GAAHTTMAPTTSHRMAPK1 | |
| SCHEMBL8070659 | 0.73 | STK10 (0.38) | GAAALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL16158923 | 0.73 | HTR1A (0.37) | GAAALDH1A1LTA4HKMT2APOLB | |
| SCHEMBL28846076 | 0.72 | HTR1A (0.51) | LTA4HHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |