Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.46 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25165760 | 0.89 | TNFRSF1A (0.62) | TNFRSF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL1901692 | 0.85 | PTPN22 (0.61) | FFAR1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL1901690 | 0.85 | PTPN22 (0.61) | FFAR1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL1901689 | 0.85 | PTPN22 (0.61) | FFAR1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6791506 | 0.83 | FFAR1 (0.65) | FFAR1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3135714 | 0.83 | TNFRSF1A (0.57) | TNFRSF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3135706 | 0.83 | TNFRSF1A (0.57) | TNFRSF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3135718 | 0.83 | TNFRSF1A (0.57) | TNFRSF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL25165309 | 0.80 | TNFRSF1A (0.59) | TNFRSF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7859609 | 0.73 | TNFRSF1A (0.49) | TNFRSF1AALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | TNFRSF1A 212/4885FFAR1 3863/4885ALDH1A1 4227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.