Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 2/20 | 0.44 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487824 | 0.84 | TBXA2R (0.50) | TBXA2RCCR2CXCR1CXCR2ACLY | |
| SCHEMBL3709166 | 0.82 | CXCR2 (0.63) | CCR2CXCR1CXCR2GPR27AVPR2 | |
| SCHEMBL7940030 | 0.82 | HDAC1 (0.50) | CCR2CXCR1CXCR2ACLYGPR27 | |
| SCHEMBL7490402 | 0.82 | GPR27 (0.51) | CCR2CXCR1CXCR2GPR27AVPR2 | |
| SCHEMBL7496445 | 0.82 | ACLY (0.52) | CCR2CXCR1CXCR2ACLYGPR27 | |
| SCHEMBL7553684 | 0.81 | MEN1 (0.57) | CCR2ACLYKMT2AMEN1 | |
| SCHEMBL7589336 | 0.81 | SLC22A12 (0.54) | CCR2ACLYKAT6ASLC22A12 | |
| SCHEMBL7853764 | 0.81 | NAMPT (0.50) | CCR2CXCR1CXCR2 | |
| SCHEMBL7493701 | 0.81 | STAT3 (0.51) | CCR2CXCR1CXCR2ACLYGPR27 | |
| SCHEMBL8684465 | 0.80 | CXCR1 (0.43) | CCR2CXCR1CXCR2ACLYGPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912505-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6133319-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0912505-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049680-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |