SCHEMBL2534140

SCHEMBL2534140

CCCOC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EHMT1 Q9H9B1 1/20 0.70
ADORA1 P30542 5/20 0.69
SMN1; SMN2 Q16637 3/20 0.69
ADORA3 P0DMS8 2/20 0.69
ADORA2A P29274 2/20 0.69
ADORA2B P29275 2/20 0.69
DPP4 P27487 1/20 0.69
MEN1 O00255 1/20 0.69
SLC28A1 O00337 1/20 0.69
MAP3K7 O43318 1/20 0.69
SLC28A2 O43868 1/20 0.69
GAPDH P04406 1/20 0.69
MAPK1 P28482 1/20 0.69
STAT6 P42226 1/20 0.69
PI4KA P42356 1/20 0.69
KMT2A Q03164 1/20 0.69
PI4K2B Q8TCG2 1/20 0.69
DOT1L Q8TEK3 1/20 0.69
SLC29A1 Q99808 1/20 0.69
PI4K2A Q9BTU6 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8671037 0.94 EHMT1 (0.74) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL8671033 0.94 EHMT1 (0.74) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL29936475 0.94 EHMT1 (0.74) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL8328542 0.93 ADORA1 (0.74) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL1637468 0.93 EHMT1 (0.76) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL9231760 0.93 EHMT1 (0.76) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL1920531 0.92 EHMT1 (0.74) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL10865966 0.92 EHMT1 (0.74) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL3698839 0.91 ADORA3 (0.72) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A
SCHEMBL873362 0.91 ADORA3 (0.72) EHMT1ADORA1SMN1; SMN2ADORA3ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994023723-A1 ADENOSINE RECEPTOR AGONISTS FOR THE PROMOTION OF WOUND HEALING NEW YORK UNIVERSITY (US) 1994-10-27 WO claimed
US-20240229036-A9 NUCLEIC ACID MEDICINE EXPRESSING SPLICING VARIANT OF MYOSTATIN KNC LABORATORIES CO., LTD. (JP) 2024-07-11 US disclosed
US-20240132893-A1 NUCLEIC ACID MEDICINE EXPRESSING SPLICING VARIANT OF MYOSTATIN KNC LABORATORIES CO., LTD. (JP) 2024-04-25 US disclosed
US-11958878-B2 Therapeutic agent for glycogen storage disease type IA DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-04-16 US disclosed
EP-4299743-A1 NUCLEIC ACID MEDICINE EXPRESSING SPLICING VARIANT OF MYOSTATIN KNC Laboratories Co., Ltd. (JP) 2024-01-03 EP disclosed
US-20230272403-A1 ANTISENSE OLIGONUCLEOTIDE INDUCING EXON SKIPPING OF ANGIOTENSIN CONVERTING ENZYME 2 GENE KNC LABORATORIES CO., LTD. (JP) 2023-08-31 US disclosed
EP-4201484-A1 ANTISENSE NUCLEIC ACID INDUCING EXON SKIPPING OF ANGIOTENSIN CONVERTING ENZYME 2 GENE KNC Laboratories Co., Ltd. (JP) 2023-06-28 EP disclosed
EP-3146970-B1 NUCLEIC ACID DRUG FOR INDUCING SKIPPING OF VARIANT EXON OF CD44 GENE AND INCREASING EXPRESSION OF NORMAL TYPE CD44 MRNA KNC LABORATORIES CO LTD (JP) 2022-11-02 EP disclosed
US-20220220478-A1 NUCLEIC ACID DRUG SUPPRESSING PRODUCTION OF MYOSTATIN GENE MRNA KNC LABORATORIES CO., LTD. (JP) 2022-07-14 US disclosed
EP-3995153-A1 NUCLEIC ACID DRUG SUPPRESSING PRODUCTION OF MYOSTATIN GENE MRNA KNC Laboratories Co., Ltd. (JP) 2022-05-11 EP disclosed
EP-2364086-B1 NOVEL ANTITHROMBOTIC DIADENOSINE TETRAPHOSPHATES AND RELATED ANALOGS GLSYNTHESIS INC (US) 2016-09-14 EP disclosed
US-8575127-B2 Antithrombotic diadenosine tetraphosphates and related analogs GLSYNTHESIS INC. (US) 2013-11-05 US disclosed
US-20110257252-A1 NOVEL ANTITHROMBOTIC DIADENOSINE TETRAPHOSPHATES AND RELATED ANALOGS GLSYNTHESIS INC. (US) 2011-10-20 US disclosed
WO-1994023723-A1 ADENOSINE RECEPTOR AGONISTS FOR THE PROMOTION OF WOUND HEALING NEW YORK UNIVERSITY (US) 1994-10-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11958878-B2 Therapeutic agent for glycogen storage disease type IA G6PC1, GAA, GBA3 EHMT1 4605/4885ADORA1 2515/4885SMN1; SMN2 298/4885
US-20220220478-A1 NUCLEIC ACID DRUG SUPPRESSING PRODUCTION OF MYOSTATIN GENE MRNA MYOF, MSTN, MTPN EHMT1 2923/4885ADORA1 2537/4885SMN1; SMN2 65/4885
US-20110257252-A1 NOVEL ANTITHROMBOTIC DIADENOSINE TETRAPHOSPHATES AND RELATED ANALOGS GP6, P2RY6, PFKP EHMT1 2128/4885ADORA1 79/4885SMN1; SMN2 2795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.