Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | DDO | Q99489 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861387 | 0.84 | KDM5A (0.50) | KDM4ETDP1MAPTKDM5AKDM5B | |
| SCHEMBL7862448 | 0.82 | KMT2A (0.38) | KDM4ETDP1ERN1MAPTPADI4 | |
| SCHEMBL7860205 | 0.80 | MEN1 (0.42) | KDM4EMAPTNPC1RAB9AKDM5A | |
| SCHEMBL1033282 | 0.79 | GRIN2D (0.43) | KDM4ETDP1GRIK1GRIA1GRIA2 | |
| SCHEMBL7865102 | 0.78 | MEN1 (0.38) | KDM4ETDP1CYP3A4MAPTRAB9A | |
| SCHEMBL7861641 | 0.78 | TSHR (0.38) | KDM4ECYP3A4MAPTPADI4NPC1 | |
| SCHEMBL2483507 | 0.77 | KDM4E (0.50) | KDM4ETDP1CYP3A4NPC1RAB9A | |
| SCHEMBL7826753 | 0.77 | KDM4E (0.38) | KDM4ETDP1GRIK1GRIA1GRIA2 | |
| SCHEMBL7593043 | 0.76 | HDAC4 (0.42) | ERN1MAPTKDM5A | |
| SCHEMBL7556667 | 0.75 | HSD17B1 (0.34) | KDM4EMAPTPADI4PARP1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097139-A1 | QUINOLINE DERIVATIVES | Active Biotech AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003992-A1 | QUINOLINE DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2000-01-27 | — | — | WO | disclosed |