SCHEMBL7862001

SCHEMBL7862001

CC(=O)N[C@@H](Cc1cccc(CNC(=O)c2cccc(NC=NN)c2)c1)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.48
ITGB1 P05556 1/20 0.48
ITGAV P06756 1/20 0.48
ITGA2B P08514 1/20 0.48
ITGB5 P18084 1/20 0.48
ALDH1A1 P00352 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
GPR132 Q9UNW8 1/20 0.41
GRB2 P62993 1/20 0.41
CTSV O60911 1/20 0.41
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
CTSS P25774 1/20 0.41
CTSK P43235 1/20 0.41
CHRM3 P20309 1/20 0.41
SLC7A5 Q01650 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.41
FNTA P49354 1/20 0.41
FNTB P49356 1/20 0.41
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7861998 1.00 ITGB3 (0.48) ITGB3ITGB1ITGAVITGA2BITGB5
SCHEMBL7864267 0.87 TP53 (0.45) ALDH1A1SLC7A5SIRT2TP53TSHR
SCHEMBL7864776 0.85 PPARG (0.53) LMNABCHE
SCHEMBL7864217 0.85 ITGB3 (0.52) ITGB3ITGB1ITGAVITGA2BITGB5
SCHEMBL7861992 0.85 ITGB3 (0.52) ITGB3ITGB1ITGAVITGA2BITGB5
SCHEMBL7377339 0.84 ITGB1 (0.68) ITGB3ITGB1ITGAVITGA2BITGB5
SCHEMBL7377332 0.84 ITGB1 (0.68) ITGB3ITGB1ITGAVITGA2BITGB5
SCHEMBL7864788 0.83 SIRT2 (0.44) ALDH1A1SIRT2GAAHSD17B10CFD
SCHEMBL7856483 0.83 SIRT2 (0.48) ALDH1A1SIRT2GAAHSD17B10CFD
SCHEMBL6775970 0.82 GPR132 (0.49) ITGB3ITGB1ITGAVITGA2BITGB5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889877-B1 META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS SEARLE & CO (US) 2001-08-29 EP claimed
EP-0889877-A1 META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS G.D. SEARLE & CO. (US) 1999-01-13 EP claimed
WO-1997036862-A1 META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS G.D. SEARLE & CO. (US) 1997-10-09 WO claimed
EP-0889877-B1 META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS SEARLE & CO (US) 2001-08-29 EP disclosed
EP-0889877-A1 META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS G.D. SEARLE & CO. (US) 1999-01-13 EP disclosed
WO-1997036862-A1 META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS G.D. SEARLE & CO. (US) 1997-10-09 WO disclosed