Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720466 | 0.93 | TOP2A (0.45) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| SCHEMBL9720459 | 0.92 | TOP2A (0.45) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9720598 | 0.92 | TOP2A (0.45) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9720534 | 0.91 | TOP2A (0.44) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| SCHEMBL9720497 | 0.91 | TOP2A (0.43) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| SCHEMBL9720525 | 0.89 | ADRB2 (0.46) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| SCHEMBL7866482 | 0.87 | TOP2A (0.67) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL4306583 | 0.86 | KMT2A (0.60) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| SCHEMBL29576844 | 0.86 | KMT2A (0.60) | TOP2ATOP2BADRB2KDM4EALDH1A1 | |
| SCHEMBL10727441 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700399-B1 | 36-DERIVATIVES OF RIFAMYCINS AND THEIR USE AS ANTIMICROBIAL AGENTS | LEPETIT SPA (IT) | 2001-10-04 | — | — | EP | disclosed |
| US-5786350-A | CONDENSATION; HYDROLYSIS; DEPROTECTING | GRUPPO LEPETIT S.P.A. (IT) | 1998-07-28 | — | — | US | disclosed |
| EP-0700399-A1 | 36-DERIVATIVES OF RIFAMYCINS AND THEIR USE AS ANTIMICROBIAL AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994028002-A1 | 36-DERIVATIVES OF RIFAMYCINS AND THEIR USE AS ANTIMICROBIAL AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1994-12-08 | — | — | WO | disclosed |
| US-5169853-A | Antibacterial agents; administering to mammals for infection | STERLING DRUG INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5075319-A | Bactericides | STERLING DRUG INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0417669-A2 | Pyridinyl-quinolone compounds, their preparation and use | STERLING WINTHROP INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0309789-A1 | 4-Oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof | STERLING WINTHROP INC. (US) | 1989-04-05 | — | — | EP | disclosed |