Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861710 | 0.81 | GSK3B (0.49) | GSK3BPOLBCYP3A4MMP2MMP9 | |
| SCHEMBL3025973 | 0.78 | GSK3B (0.72) | GSK3BPOLBCYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL14711680 | 0.75 | GSK3B (1.00) | GSK3BPOLBCYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL7860396 | 0.74 | NPC1 (0.60) | POLBCYP3A4MMP2MMP9NPC1 | |
| SCHEMBL1748168 | 0.74 | GSK3B (0.46) | GSK3BPOLBSMN1; SMN2NPC1HSD11B1 | |
| SCHEMBL7861847 | 0.74 | HSP90AA1 (0.50) | GSK3BCYP3A4SMN1; SMN2NPC1HSD11B1 | |
| SCHEMBL27704908 | 0.73 | MAPT (0.47) | GSK3BCYP3A4SMN1; SMN2NPC1HSD11B1 | |
| SCHEMBL7861873 | 0.72 | GSK3B (0.59) | GSK3BPOLBCYP3A4MMP2MMP9 | |
| SCHEMBL8944830 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2CA12CA9MEN1KMT2A | |
| SCHEMBL6293053 | 0.71 | MMP2 (0.43) | GSK3BMMP2MMP9SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923529-B1 | SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER AG (US) | 2001-09-19 | — | — | EP | disclosed |
| CN-1225620-A | Substituted 4-arylbutanoic acid derivatives as matrix metalloproteinase inhibitors | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |
| EP-0923529-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | Bayer Corporation (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997043237-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |