Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861865 | 0.82 | THRA (0.41) | NPSR1POLBSMN1; SMN2GAA | |
| SCHEMBL7862778 | 0.81 | GSK3B (0.59) | GSK3BPOLBCYP3A4SMN1; SMN2KMT2A | |
| SCHEMBL7860396 | 0.73 | NPC1 (0.60) | NPSR1POLBCYP3A4KMT2AMEN1 | |
| SCHEMBL3025973 | 0.71 | GSK3B (0.72) | GSK3BPOLBCYP3A4SMN1; SMN2KMT2A | |
| SCHEMBL6293053 | 0.70 | MMP2 (0.43) | GSK3BSMN1; SMN2MMP2MMP9NPC1 | |
| SCHEMBL4262187 | 0.69 | MAPT (0.43) | KMT2AMEN1MMP1ALDH1A1MAPK1 | |
| SCHEMBL14711680 | 0.68 | GSK3B (1.00) | GSK3BNPSR1POLBCYP3A4SMN1; SMN2 | |
| SCHEMBL7574583 | 0.67 | MEN1 (0.46) | NPSR1KMT2AMEN1MMP1MMP2 | |
| SCHEMBL6296941 | 0.67 | NPC1 (0.42) | POLBSMN1; SMN2KMT2AMEN1MMP2 | |
| SCHEMBL23388863 | 0.67 | ALDH1A1 (0.46) | NPSR1SMN1; SMN2KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923529-B1 | SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER AG (US) | 2001-09-19 | — | — | EP | disclosed |
| CN-1225620-A | Substituted 4-arylbutanoic acid derivatives as matrix metalloproteinase inhibitors | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |
| EP-0923529-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | Bayer Corporation (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997043237-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |