Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.44 |
| ▸ | PPARG | P37231 | 14/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754112 | 0.91 | PPARG (0.45) | PPARAPPARGPPARDADORA3KDM4E | |
| SCHEMBL11763480 | 0.89 | PPARG (0.44) | PPARAPPARGPPARDADORA3KDM4E | |
| SCHEMBL9753649 | 0.89 | ALOX15 (0.42) | PPARAPPARGPPARDMAPTALOX15 | |
| SCHEMBL5707517 | 0.84 | LMNA (0.49) | PPARAPPARGKDM4EL3MBTL1 | |
| SCHEMBL28258662 | 0.84 | PPARG (0.42) | PPARAPPARGPPARDADORA3KDM4E | |
| SCHEMBL26135414 | 0.84 | PPARG (0.45) | PPARAPPARGPPARDADORA3KDM4E | |
| SCHEMBL27605264 | 0.83 | PIN1 (0.46) | PPARAPPARGKDM4EMAPTNPSR1 | |
| SCHEMBL28212657 | 0.80 | GAA (0.44) | PPARAPPARGPPARDL3MBTL1 | |
| SCHEMBL10903534 | 0.80 | ALDH1A1 (0.46) | PPARAPPARGPPARDADORA3KDM4E | |
| SCHEMBL28193083 | 0.80 | MAPT (0.41) | PPARAPPARGPPARDMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |
| WO-1999010374-A1 | CYCLOSPORIN A CONJUGATES AND USES THEREFOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-03-04 | — | — | WO | disclosed |