Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.47 |
| ▸ | ITGAV | P06756 | 12/20 | 0.47 |
| ▸ | EEF2K | O00418 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863260 | 1.00 | ITGB3 (0.47) | ITGB3ITGAVEEF2KALDH1A1ATM | |
| SCHEMBL7864314 | 0.87 | ITGB3 (0.58) | ITGB3ITGAVEEF2KALDH1A1ATM | |
| SCHEMBL7864311 | 0.87 | ITGB3 (0.58) | ITGB3ITGAVEEF2KALDH1A1ATM | |
| SCHEMBL8501499 | 0.82 | ITGB3 (0.46) | ITGB3ITGAV | |
| SCHEMBL7863267 | 0.81 | TGFBR1 (0.41) | ALDH1A1L3MBTL1MEN1KMT2AF2 | |
| SCHEMBL7861968 | 0.75 | TGFBR1 (0.39) | ALDH1A1L3MBTL1MEN1KMT2AF2 | |
| SCHEMBL7864640 | 0.75 | TGFBR1 (0.39) | ALDH1A1L3MBTL1MEN1KMT2AF2 | |
| SCHEMBL3441384 | 0.74 | BDKRB1 (0.51) | EEF2KALDH1A1ATML3MBTL1 | |
| SCHEMBL7864316 | 0.74 | GBA1 (0.41) | ITGB3ITGAVALDH1A1L3MBTL1MEN1 | |
| SCHEMBL7861844 | 0.73 | CA1 (0.47) | ALDH1A1L3MBTL1MEN1KMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |