Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 9/20 | 0.40 |
| ▸ | TMPRSS6 | Q8IU80 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864316 | 0.87 | GBA1 (0.41) | F2TMPRSS6ALDH1A1L3MBTL1CA1 | |
| SCHEMBL7863178 | 0.81 | ITGB3 (0.47) | F2TMPRSS6ALDH1A1L3MBTL1CA1 | |
| SCHEMBL7863260 | 0.81 | ITGB3 (0.47) | F2TMPRSS6ALDH1A1L3MBTL1CA1 | |
| SCHEMBL7864643 | 0.77 | ALDH1A1 (0.39) | TGFBR1F2ALDH1A1L3MBTL1CA1 | |
| SCHEMBL7864723 | 0.75 | TGFBR1 (0.38) | TGFBR1F2ALDH1A1L3MBTL1CA1 | |
| SCHEMBL7861846 | 0.74 | CA1 (0.44) | TGFBR1ALDH1A1L3MBTL1CA1CA2 | |
| SCHEMBL7864311 | 0.74 | ITGB3 (0.58) | ALDH1A1L3MBTL1 | |
| SCHEMBL7864314 | 0.74 | ITGB3 (0.58) | ALDH1A1L3MBTL1 | |
| SCHEMBL7861976 | 0.73 | CA12 (0.43) | TGFBR1ALDH1A1L3MBTL1CA1CA2 | |
| SCHEMBL7861968 | 0.70 | TGFBR1 (0.39) | TGFBR1F2ALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |