Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815921 | 0.85 | THRB (0.52) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL6814197 | 0.82 | LMNA (0.66) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL6815927 | 0.78 | THRB (0.47) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL7665708 | 0.77 | MAPT (0.53) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL6816771 | 0.76 | THRB (0.68) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL6815074 | 0.72 | THRB (0.65) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL15707390 | 0.71 | MAPT (0.70) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL7074215 | 0.71 | LMNA (0.56) | THRBMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3786493 | 0.70 | L3MBTL1 (0.44) | MAPTALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6810924 | 0.70 | THRB (0.65) | THRBMAPTTP53ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137632-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034238-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |