Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 4/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TK2 | O00142 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370048 | 0.93 | RNASE1 (0.38) | RNASE1TK1TK2 | |
| SCHEMBL1727535 | 0.91 | RNASE1 (0.40) | RNASE1TK1TK2 | |
| SCHEMBL1706305 | 0.87 | RNASE1 (0.38) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL9755145 | 0.87 | RNASE1 (0.38) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL29834197 | 0.86 | TK1 (0.36) | RNASE1TK1TK2 | |
| SCHEMBL8920654 | 0.85 | RNASE1 (0.36) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL7640415 | 0.85 | RNASE1 (0.38) | RNASE1TK1TK2 | |
| SCHEMBL29834214 | 0.84 | RNASE1 (0.37) | RNASE1TK1TK2 | |
| SCHEMBL29834215 | 0.84 | RNASE1 (0.37) | RNASE1TK1TK2 | |
| SCHEMBL30844899 | 0.84 | TYMP (0.33) | RNASE1TK1GRM2TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300486-B1 | CONDENSING A NUCLEOSIDE HAVING ONE HYDROXYL END BEARING A H-PHOSPHONATE GROUP AND THE OTHER PROTECTED WITH POLYMER-BOUND NUCLEOSIDE HAVING FREE HYDROXYL END IN SOLVENT WHICH SWELLS POLYMER, DEPROTECTING, REPEATING, OXIDATION | ISIS PHARMACEUTICALS, INC. | 2001-10-09 | — | — | US | disclosed |
| US-5519126-A | COMBATTING DISEASES BY BIOCHEMICL INTERVENTION AT THE RNA AND DNA LEVEL | UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1996-05-21 | — | — | US | disclosed |
| US-5204455-A | Monomethoxytrityl protected oligonucleotides bound to a solid support | ISIS PHARMACEUTICALS, INC. | 1993-04-20 | — | — | US | disclosed |
| US-5164491-A | Large scale synthesis of oligonucleotides and their associated analogs | GILEAD SCIENCES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0406309-A4 | OLIGONUCLEOTIDE N-ALKYLPHOSPHORAMIDATES | — | 1992-08-19 | — | — | EP | disclosed |
| EP-0406309-A1 | OLIGONUCLEOTIDE N-ALKYLPHOSPHORAMIDATES | THE UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1991-01-09 | — | — | EP | disclosed |
| EP-0214908-B1 | COMPOUNDS CONTAINING AN OLIGONUCLEOTIDE SEQUENCE LINKED TO AN INTERCALATING AGENT AND TO AN ACTIVABLE CHEMICAL GROUP, THEIR SYNTHESIS AND APPLICATIONS TO ARTIFICIAL SEQUENCE-SPECIFIC NUCLEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1990-11-07 | — | — | EP | disclosed |
| WO-1989009221-A1 | OLIGONUCLEOTIDE N-ALKYLPHOSPHORAMIDATES | UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1989-10-05 | — | — | WO | disclosed |
| EP-0214908-A1 | Compounds containing an oligonucleotide sequence linked to an intercalating agent and to an activable chemical group, their synthesis and applications to artificial sequence-specific nucleases | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1987-03-18 | — | — | EP | disclosed |
| EP-0073826-A1 | RAPID SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES USING PHOSPHORUS OXYCHLORIDE ACTIVATION | BIORESEARCH INC. (US) | 1983-03-16 | — | — | EP | disclosed |
| WO-1982003079-A1 | RAPID SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES USING PHOSPHORUS OXYCHLORIDE ACTIVATION | BIORESEARCH INC (US) | 1982-09-16 | — | — | WO | disclosed |