Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869485 | 0.90 | ADORA2B (0.69) | ADORA2BADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL7866617 | 0.87 | ADORA2B (0.62) | ADORA2BADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL7866628 | 0.79 | ADORA2B (0.61) | ADORA2BADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL7866612 | 0.78 | ADORA2B (0.77) | ADORA2BADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL9706609 | 0.74 | HPGD (0.49) | ADORA2BADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL9706596 | 0.73 | ADORA2A (0.41) | ADORA2BADORA3ADORA1CYP3A4HPGD | |
| SCHEMBL7866293 | 0.71 | ADORA2B (0.55) | ADORA2BADORA1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5229753 | 0.71 | ADORA2B (0.55) | ADORA2BADORA1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7423089 | 0.70 | ADORA2A (0.39) | ADORA2BADORA2A | |
| SCHEMBL5230505 | 0.69 | ADORA2B (0.66) | ADORA2BADORA3ADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306847-B1 | ANTIALLERGENS AND BRONCHODILATOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-0884318-A1 | FUSED PURINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1998-12-16 | — | — | EP | disclosed |