Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866628 | 0.82 | ADORA2B (0.61) | ADORA2BADORA2AALDH1A1HSD17B10KDM4E | |
| SCHEMBL10675027 | 0.82 | ADORA2B (0.70) | ADORA2BADORA2AALDH1A1HSD17B10KDM4E | |
| SCHEMBL7869485 | 0.81 | ADORA2B (0.69) | ADORA2BADORA2AALDH1A1HSD17B10KDM4E | |
| SCHEMBL7866293 | 0.75 | ADORA2B (0.55) | ADORA2BADORA2AALDH1A1HSD17B10KDM4E | |
| SCHEMBL9706669 | 0.73 | ADORA2A (0.45) | ADORA2BADORA2AHSD17B10HPGDADORA1 | |
| SCHEMBL7420292 | 0.72 | ADORA1 (0.44) | ADORA2BADORA2AHSD17B10HPGDADORA1 | |
| SCHEMBL7863965 | 0.71 | ADORA2B (0.58) | ADORA2BADORA2AALDH1A1HSD17B10HPGD | |
| SCHEMBL9765885 | 0.71 | ADORA2B (1.00) | ADORA2BADORA2AALDH1A1HSD17B10HPGD | |
| SCHEMBL7423540 | 0.70 | ADORA2A (0.45) | ADORA2BADORA2A | |
| SCHEMBL5231243 | 0.70 | PDE2A (0.46) | ADORA2BADORA2AHSD17B10HPGDADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |