SCHEMBL7864205

SCHEMBL7864205

CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)OCC#Cc2cccnc2)C1C1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.35
ADORA3 P0DMS8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7871436 0.89 TSHR (0.38) TSHRADORA3
SCHEMBL7873370 0.89 ADORA3 (0.37) TSHRADORA3
SCHEMBL7864163 0.88 ADORA3 (0.34) TSHRADORA3
SCHEMBL8325693 0.86 MAPT (0.38)
SCHEMBL7872515 0.86 ADORA3 (0.38) TSHRADORA3
SCHEMBL7864225 0.85 ADORA3 (0.41) TSHRADORA3
SCHEMBL7871376 0.85 ADORA3 (0.37) TSHRADORA3
SCHEMBL7869604 0.84 ADORA3 (0.40) TSHRADORA3
SCHEMBL7864174 0.84 ADORA3 (0.37) TSHRADORA3
SCHEMBL7876073 0.84 ADORA3 (0.37) TSHRADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6306853-B1 DICARBOXYLIC ESTER DERIVATIVES OF DIHYDROPYRIDINE COMPOUNDS NIKKEN CHEMICALS CO., LTD. (JP) 2001-10-23 US disclosed
EP-1055672-A1 1,4-DIHYDROPYRIDINE DERIVATIVES Nikken Chemicals Company, Limited (JP) 2000-11-29 EP disclosed