Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 10/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.53 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | PPIF | P30405 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861066 | 0.96 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CNISCHNPC1 | |
| SCHEMBL7861123 | 0.90 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CNISCHNPC1 | |
| SCHEMBL7861307 | 0.86 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CNISCHNPC1 | |
| SCHEMBL7860118 | 0.85 | ADRA2B (0.50) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL7861142 | 0.83 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CNISCHNPC1 | |
| SCHEMBL7861283 | 0.83 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CNISCHNPC1 | |
| SCHEMBL7862258 | 0.81 | ADRA2B (0.50) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL9440611 | 0.80 | NISCH (0.50) | ADRA2AADRA2BADRA2CNISCHNPC1 | |
| SCHEMBL7860109 | 0.75 | ADRA2B (0.47) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL7859939 | 0.74 | ADRA2B (0.64) | ADRA2AADRA2BADRA2CNISCHMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | claimed |
| US-5407954-A | Serotonin antagonism; treats depression, anxiety, hypertension and migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-04-18 | — | — | US | claimed |
| WO-1993016051-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | claimed |
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | disclosed |
| US-5407954-A | Serotonin antagonism; treats depression, anxiety, hypertension and migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-04-18 | — | — | US | disclosed |
| WO-1993016051-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | disclosed |