Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 14/20 | 0.50 |
| ▸ | MAOA | P21397 | 6/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440600 | 0.85 | NISCH (0.52) | NISCHMAOAMAOBADRA1AADRA1D | |
| SCHEMBL9440693 | 0.85 | NISCH (0.52) | NISCHMAOAMAOBADRA1AADRA1D | |
| SCHEMBL7861283 | 0.83 | ADRA2A (0.50) | NISCHMAOAMAOBNPC1MEN1 | |
| SCHEMBL7861142 | 0.83 | ADRA2A (0.50) | NISCHMAOAMAOBNPC1MEN1 | |
| SCHEMBL7864328 | 0.80 | ADRA2A (0.53) | NISCHMAOAMAOBNPC1MEN1 | |
| SCHEMBL9440508 | 0.79 | NISCH (0.53) | NISCHMAOAMAOBADRA1AADRA1D | |
| SCHEMBL7861123 | 0.78 | ADRA2A (0.48) | NISCHMAOAMAOBNPC1MEN1 | |
| SCHEMBL9440635 | 0.77 | NISCH (0.51) | NISCHMAOAMAOBADRA1AADRA1D | |
| SCHEMBL7861066 | 0.76 | ADRA2A (0.53) | NISCHMAOAMAOBNPC1MEN1 | |
| SCHEMBL9440587 | 0.76 | NISCH (0.46) | NISCHMAOAMAOBNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | claimed |
| EP-0625969-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | disclosed |