Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | RXRG | P48443 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10713479 | 0.83 | ADRB2 (0.54) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL7865011 | 0.83 | MAOB (0.68) | MAOBALDH1A1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL2984321 | 0.81 | MAOB (0.74) | MAOBALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL18152365 | 0.77 | SYK (0.49) | LMNATDP1L3MBTL1PTGER1 | |
| SCHEMBL19225761 | 0.77 | NPC1 (0.60) | RXRAMAOBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3759214 | 0.76 | RXRA (0.88) | RXRARXRBRXRGALDH1A1KDM4E | |
| Acetic Acid SCHEMBL5690407 | 0.76 | RXRA (0.72) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL17488409 | 0.76 | CYP11B1 (0.47) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL2036335 | 0.74 | RXRA (0.61) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL2981825 | 0.74 | MAOB (0.72) | MAOBALDH1A1SMN1; SMN2L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923529-B1 | SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER AG (US) | 2001-09-19 | — | — | EP | disclosed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |