SCHEMBL7865873

SCHEMBL7865873

CCCSc1c(C(F)(F)F)ccnc1OC

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.37
SLC22A12 Q96S37 1/20 0.34
NFE2L2 Q16236 2/20 0.34
KDM4E B2RXH2 1/20 0.33
APLNR P35414 1/20 0.32
LRRK2 Q5S007 1/20 0.32
AURKA O14965 1/20 0.31
KDR P35968 1/20 0.31
AURKB Q96GD4 1/20 0.31
ITGB2 P05107 1/20 0.31
ICAM1 P05362 1/20 0.31
ITGAL P20701 1/20 0.31
TRPV1 Q8NER1 1/20 0.31
LIMK1 P53667 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2E1 P05181 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C8 P10632 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31121358 1.00 AR (0.37) ARSLC22A12NFE2L2KDM4EAPLNR
SCHEMBL31563752 0.88 HPGD (0.37) ARKDM4EAPLNRLRRK2TRPV1
SCHEMBL22165804 0.88 HPGD (0.37) ARKDM4EAPLNRLRRK2TRPV1
SCHEMBL22165527 0.79 AR (0.38) ARKDM4EAPLNRHTR2CHTR2B
SCHEMBL31563751 0.79 AR (0.38) ARKDM4EAPLNRHTR2CHTR2B
SCHEMBL7870542 0.78 THRB (0.33) ARNFE2L2AURKAAURKBCYP1A2
SCHEMBL6679512 0.73 ATM (0.39) ARKDM4EAPLNRMAPTHTR2C
SCHEMBL24246943 0.72 SLC22A12 (0.44) SLC22A12NFE2L2LRRK2AURKAKDR
SCHEMBL9280550 0.71 SLC22A12 (0.40) SLC22A12NFE2L2APLNRLRRK2AURKA
SCHEMBL13415859 0.71 SLC22A12 (0.40) ARSLC22A12NFE2L2LRRK2AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3902786-B1 PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES CORTEVA AGRISCIENCE LLC (US) 2022-12-14 EP disclosed
EP-3902786-B1 PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES CORTEVA AGRISCIENCE LLC (US) 2022-12-14 EP disclosed
US-11390587-B2 Preparation of sulfonamide herbicide process intermediates CORTEVA AGRISCIENCE LLC (US) 2022-07-19 US disclosed
EP-3902786-A1 PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES Corteva Agriscience LLC (US) 2021-11-03 EP disclosed
CN-113227052-A Sulfonamide herbicide process intermediates preparation 科迪华农业科技有限责任公司 2021-08-06 CN disclosed
WO-2020139740-A1 PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES DOW AGROSCIENCES LLC (US) 2020-07-02 WO disclosed
WO-2020139740-A1 PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES DOW AGROSCIENCES LLC (US) 2020-07-02 WO disclosed
US-6303814-B1 N-[1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC 2001-10-16 US disclosed
EP-0877745-B1 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-25 EP disclosed
US-6130335-A N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 2000-10-10 US disclosed
US-6005108-A POST-EMERGENCE TOTAL VEGETATION CONTROL OR SELECTIVE CONTROL OF WEEDS IN WHEAT, RICE AND OIL-SEED RAPE CROPS JOHNSON TIMOTHY C (US) 1999-12-21 US disclosed
US-5965490-A NOVEL COMPOUNDS WITH IMPROVED SELECTIVITY TO VALUABLE CROPS AND IMPROVED TOXICOLOGICAL AND ENVIRONMENTAL ATTRIBUTES; APPLYING TO CONTROL WEEDS BY EITHER PREEMERGENCE OR POSTEMERGENCE APPLICATION DOW AGROSCIENCES LLC (US) 1999-10-12 US disclosed
US-5858924-A N-( 1, 2, 4! triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 1999-01-12 US disclosed
EP-0877745-A2 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 1998-11-18 EP disclosed
WO-1998013367-A1 N-([1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 1998-04-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11390587-B2 Preparation of sulfonamide herbicide process intermediates STS, DDX6, DHX9 AR 3512/4885SLC22A12 1524/4885NFE2L2 959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.