Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.39 |
| ▸ | CTSA | P10619 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP15 | P51511 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864160 | 0.82 | FFAR1 (0.39) | FFAR1CTSALMNACYP2C19KMT2A | |
| SCHEMBL7864754 | 0.82 | PTPN11 (0.48) | PTPN11FFAR1MMP2MMP9MMP12 | |
| SCHEMBL7866927 | 0.80 | FFAR1 (0.45) | FFAR1HDAC8 | |
| SCHEMBL7856436 | 0.80 | ITGB3 (0.48) | MEN1KMT2A | |
| SCHEMBL7863159 | 0.79 | KMT2A (0.56) | FFAR1CTSAKMT2A | |
| SCHEMBL7457204 | 0.77 | ITGB3 (0.53) | FFAR1LMNAMEN1KMT2AHDAC8 | |
| SCHEMBL7863123 | 0.77 | ITGB3 (0.39) | CTSALMNAMEN1KMT2A | |
| SCHEMBL8501227 | 0.77 | ITGB3 (0.40) | FFAR1CTSA | |
| SCHEMBL7864766 | 0.77 | ITGB3 (0.38) | FFAR1CTSACYP2C19MEN1KMT2A | |
| SCHEMBL7864712 | 0.76 | SIRT2 (0.45) | LMNAEPHX2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |