Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.74 |
| ▸ | HTR1A | P08908 | 13/20 | 0.71 |
| ▸ | DRD2 | P14416 | 11/20 | 0.71 |
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527363 | 0.90 | SLC6A4 (0.66) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL14280720 | 0.85 | OPRM1 (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL9527241 | 0.84 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7536094 | 0.84 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7543848 | 0.83 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| Oxalic Acid SCHEMBL7867306 | 0.82 | SLC6A4 (0.66) | HTR1ADRD2HTR2ASLC6A4HTR6 | |
| SCHEMBL4194997 | 0.81 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7649906 | 0.80 | HTR1A (0.83) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL1122147 | 0.80 | OPRM1 (0.71) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL1122074 | 0.79 | SLC6A4 (1.00) | HTR1ASLC6A4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |