Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HTR6 | P50406 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867252 | 0.85 | MAPT (0.62) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| SCHEMBL16802081 | 0.78 | HTR2C (0.55) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| Ru-24969 SCHEMBL2359264 | 0.77 | HTR6 (1.00) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| SCHEMBL7864917 | 0.77 | HTR6 (0.81) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| Ru-24969 SCHEMBL29390076 | 0.77 | HTR6 (1.00) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| SCHEMBL7867382 | 0.77 | CCNT1 (0.43) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| SCHEMBL5845143 | 0.75 | HTR2C (0.65) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| SCHEMBL2778860 | 0.75 | HTR6 (0.67) | KDM4EALDH1A1HTR2CHSD17B10MAPT | |
| SCHEMBL7866446 | 0.73 | CCNT1 (0.49) | CCNT1CDK9QDPR | |
| Hydrochloric Acid SCHEMBL979625 | 0.72 | QDPR (0.64) | HTR2CCCNT1CDK9QDPRCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |