Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.47 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.47 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382201 | 0.97 | ANPEP (0.71) | ANPEPHDAC6SMN1; SMN2L3MBTL1DPP8 | |
| SCHEMBL5057161 | 0.84 | ANPEP (0.54) | ANPEPHDAC6SMN1; SMN2L3MBTL1PKM | |
| SCHEMBL7879190 | 0.81 | PKM (0.54) | ANPEPHDAC6SMN1; SMN2L3MBTL1PKM | |
| SCHEMBL7383594 | 0.81 | ANPEP (0.65) | ANPEPHDAC6DPP8DPP7DPP4 | |
| SCHEMBL28341559 | 0.81 | ANPEP (0.62) | ANPEPHDAC6DPP8DPP7DPP4 | |
| SCHEMBL17646395 | 0.81 | ANPEP (0.62) | ANPEPHDAC6DPP8DPP7DPP4 | |
| Hydrochloric Acid SCHEMBL28344079 | 0.80 | ANPEP (0.61) | ANPEPHDAC6DPP8DPP7DPP4 | |
| Hydrochloric Acid SCHEMBL17646405 | 0.80 | ANPEP (0.61) | ANPEPHDAC6DPP8DPP7DPP4 | |
| SCHEMBL7873419 | 0.80 | ANPEP (1.00) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL7876536 | 0.79 | HDAC6 (0.51) | ANPEPHDAC6SMN1; SMN2L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |