SCHEMBL7876536

SCHEMBL7876536

CC(C)(SCCNC(=O)OCc1ccccc1)[C@H](N)C(=O)Nc1nccs1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.51
PKM P14618 1/20 0.48
ANPEP P15144 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
HSPA5 P11021 3/20 0.43
HSPA9 P38646 2/20 0.43
HSPA1A P0DMV8 1/20 0.43
HSPA2 P54652 1/20 0.43
KDM4E B2RXH2 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
LMNA P02545 2/20 0.41
TSHR P16473 2/20 0.41
NR3C1 P04150 4/20 0.41
USP2 O75604 1/20 0.41
PGR P06401 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7874829 0.87 ALDH1A1 (0.47) PKMSMN1; SMN2L3MBTL1HSPA5HSPA2
SCHEMBL7421285 0.85 HDAC6 (0.47) HDAC6PKMSMN1; SMN2L3MBTL1HSPA5
SCHEMBL7868066 0.79 ANPEP (0.66) HDAC6PKMANPEPSMN1; SMN2L3MBTL1
SCHEMBL7382201 0.79 ANPEP (0.71) HDAC6PKMANPEPSMN1; SMN2L3MBTL1
SCHEMBL7421060 0.75 HDAC6 (0.68) HDAC6
SCHEMBL747058 0.74 KDM4E (0.60) HDAC6PKMSMN1; SMN2L3MBTL1KDM4E
SCHEMBL7876510 0.70 PKM (0.55) HDAC6PKMSMN1; SMN2L3MBTL1HSPA5
SCHEMBL27626566 0.70 GRIN2B (0.54) HDAC6PKMSMN1; SMN2L3MBTL1KDM4E
SCHEMBL4119851 0.69 HSPA5 (0.57) HSPA5HSPA9HSPA2LMNATSHR
SCHEMBL6056907 0.69 HSPA5 (0.57) HSPA5HSPA9HSPA2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329400-B1 INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS GLAXO WELLCOME INC. 2001-12-11 US disclosed