Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.83 |
| ▸ | RAB9A | P51151 | 1/20 | 0.83 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.63 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
| ▸ | MMP1 | P03956 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436374 | 0.93 | NPC1 (0.73) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL28650786 | 0.93 | LMNA (0.76) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL656856 | 0.92 | NPC1 (0.71) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL28668863 | 0.92 | RAB9A (0.71) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL4096780 | 0.92 | NPC1 (0.71) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL1304164 | 0.92 | NPC1 (0.71) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL1304210 | 0.91 | NPC1 (1.00) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL8200487 | 0.91 | NPC1 (0.71) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL2928400 | 0.91 | NPC1 (0.87) | NPC1RAB9AF2RL1MAPTLMNA | |
| SCHEMBL10070195 | 0.89 | ALDH1A1 (0.72) | NPC1RAB9AF2RL1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600854-B1 | PHENETHYL, PHENETHYLENE, PHENETHYNE AND INDANONE DERIVATES IN COSMETIC FORMULATIONS, ESPECIALLY FOR USE IN SKIN AGEING PROCESSES | MERCK PATENT GMBH (DE) | 2016-01-27 | — | — | EP | disclosed |
| WO-2012016619-A1 | PHENETHYL, PHENETHYLENE, PHENETHYNE AND INDANONE DERIVATES IN COSMETIC FORMULATIONS, ESPECIALLY FOR USE IN SKIN AGEING PROCESSES | MERCK PATENT GMBH (DE) | 2012-02-09 | — | — | WO | disclosed |
| US-6303733-B1 | FROM BISPHENOL COMPOUNDS AND DIFLUORO DIARYLACETYLENES AND/OR ETHYNYLATED BENZOPHENONES; DIELECTRICS EMPLOYED WITH A VARIETY OF MICROELECTRONIC DEVICES, FOR EXAMPLE, INTEGRATED CIRCUITS AND MULTICHIP MODULES. | ALLIEDSIGNAL INC. | 2001-10-16 | — | — | US | disclosed |