Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.34 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589058 | 0.86 | PTPRC (0.42) | PTPRCERN1GPR35MEN1LMNA | |
| SCHEMBL5484357 | 0.86 | ERN1 (0.44) | PTPRCERN1GPR35MEN1KMT2A | |
| SCHEMBL16050105 | 0.82 | ERN1 (0.44) | PTPRCERN1MEN1LMNATHRB | |
| SCHEMBL3360989 | 0.82 | PTPRC (0.47) | PTPRCERN1MEN1LMNATHRB | |
| SCHEMBL1341637 | 0.79 | ELANE (0.43) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL11728230 | 0.79 | ALDH1A1 (0.59) | PTPRCGPR35MEN1KMT2ATDP1 | |
| SCHEMBL643993 | 0.79 | ALDH1A1 (0.59) | PTPRCERN1MEN1LMNATHRB | |
| SCHEMBL16050103 | 0.79 | PTPRC (0.48) | PTPRCERN1MEN1LMNATHRB | |
| SCHEMBL2841295 | 0.77 | GPR35 (0.59) | PTPRCGPR35MEN1KMT2ACYP2A6 | |
| SCHEMBL10395877 | 0.76 | MAPT (0.47) | MEN1LMNATHRBBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789701-B1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2001-02-07 | — | — | EP | disclosed |
| EP-0789701-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-20 | — | — | EP | disclosed |
| US-5552399-A | TREATMENT OR PREVENTION OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| WO-1996014320-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-17 | — | — | WO | disclosed |