Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957602 | 0.81 | ACKR3 (0.48) | MEN1KMT2ASMN1; SMN2KDM4EPRMT5 | |
| Bromide SCHEMBL6968359 | 0.80 | ACKR3 (0.48) | MEN1KMT2ASMN1; SMN2KDM4EPRMT5 | |
| Hydrochloric Acid SCHEMBL9213892 | 0.80 | ACKR3 (0.48) | MEN1KMT2ASMN1; SMN2KDM4EPRMT5 | |
| Bromide SCHEMBL7865761 | 0.76 | SMN1; SMN2 (0.59) | MEN1KMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL9082384 | 0.75 | FAAH (0.52) | MEN1KMT2ASMN1; SMN2KDM4EPRMT5 | |
| SCHEMBL10978742 | 0.73 | ACHE (0.66) | MEN1KMT2ASMN1; SMN2KDM4EPRMT5 | |
| SCHEMBL31134754 | 0.73 | ACHE (0.66) | MEN1KMT2ASMN1; SMN2KDM4EPRMT5 | |
| SCHEMBL8304595 | 0.73 | L3MBTL1 (0.55) | MEN1KMT2AKDM4EHTTNPSR1 | |
| SCHEMBL14234933 | 0.73 | SIGMAR1 (0.64) | MEN1KMT2AKDM4EHTTNPSR1 | |
| Hydrochloric Acid SCHEMBL6968014 | 0.72 | L3MBTL1 (0.54) | MEN1KMT2AKDM4EHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | claimed |
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |