Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202595 | 0.77 | REN (1.00) | RENKCNH2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL10202584 | 0.66 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL7871427 | 0.66 | REN (0.56) | RENKCNH2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL555642 | 0.66 | REN (0.75) | RENKCNH2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL7871268 | 0.64 | REN (0.88) | RENKCNH2CYP3A4 | |
| SCHEMBL10202591 | 0.62 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL23982537 | 0.57 | CHRNB2 (0.46) | RENKCNH2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL25556701 | 0.57 | OPRM1 (0.38) | — | |
| SCHEMBL556854 | 0.55 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL654834 | 0.55 | DRD2 (0.54) | RENKCNH2CYP3A4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |