Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.60 |
| ▸ | CCND1 | P24385 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163392 | 0.91 | MAPK1 (0.60) | CDK4CCND1MAPK1LMNAKMT2A | |
| SCHEMBL9324414 | 0.85 | LMNA (0.57) | CDK4CCND1MAPK1LMNAKMT2A | |
| SCHEMBL28255980 | 0.83 | CDK4 (0.57) | CDK4CCND1LMNAKMT2A | |
| SCHEMBL28257569 | 0.82 | CDK4 (0.55) | CDK4CCND1LMNAKMT2A | |
| SCHEMBL27467119 | 0.81 | KMT2A (0.56) | CDK4CCND1MAPK1LMNAKMT2A | |
| SCHEMBL3995842 | 0.80 | CDK4 (0.70) | CDK4CCND1MAPK1LMNAKMT2A | |
| SCHEMBL31083788 | 0.80 | CDK4 (0.70) | CDK4CCND1MAPK1LMNAKMT2A | |
| SCHEMBL8792687 | 0.77 | TNF (0.70) | CDK4CCND1MAPK1LMNA | |
| SCHEMBL3821123 | 0.77 | MAPK1 (0.55) | CDK4CCND1MAPK1LMNAKMT2A | |
| SCHEMBL31211624 | 0.77 | MAPK1 (0.55) | CDK4CCND1MAPK1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657458-B1 | Protein kinase C inhibitors | LILLY CO ELI (US) | 2001-08-22 | — | — | EP | disclosed |
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-6057440-A | AMINATION AND DEETHERIFICATION OF BISINDOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| US-5843935-A | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5821365-A | COMPOUNDS AS ENZYME INHIBITORS FOR KINASES FORMED BY REACTION OF AMINE WITH ANHYDRIDE GROUP TO FORM INDOLMALEIMIDE MACROCYCLES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5780461-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| US-5739322-A | INHIBITORS OF PROTEIN KINASE C IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-14 | — | — | US | disclosed |
| US-5719175-A | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| US-5698578-A | BIS-INDOLEMALEIMIDE MACROCYCLE DERIVATIVES; TREATMENT OF DIABETES | ELI LILLY AND COMPANY (US) | 1997-12-16 | — | — | US | disclosed |
| US-5696108-A | ADMINISERING TO THE MAMMAL BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVE AS ANTIINFLAMMATORY AGENT | ELI LILLY AND COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5674862-A | USING A BIS(INDOLEMALEIMIDE) MACROCYCLE DERIVATIVE | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| US-5624949-A | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-5621098-A | ALKYLATION OF THE CORRESPONDING BISINDOLE COMPOUND; CYCLIZATION; PROTEIN C KINEASE INHIBITOR | ELI LILLY AND COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| US-5552396-A | BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVES, | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0657458-A1 | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |