Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | CDK4 | P11802 | 4/20 | 0.52 |
| ▸ | CCND1 | P24385 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163392 | 0.84 | MAPK1 (0.60) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL3330677 | 0.83 | KMT2A (0.51) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL7873205 | 0.81 | CDK4 (0.60) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL27624745 | 0.81 | KMT2A (0.57) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL9324414 | 0.78 | LMNA (0.57) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL9701534 | 0.77 | KMT2A (0.71) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL30074152 | 0.77 | KMT2A (0.71) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL6469417 | 0.77 | CDK4 (0.61) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL30057745 | 0.77 | CDK4 (0.61) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL27342099 | 0.75 | MTNR1A (0.59) | CYP2C19MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104016989-A | Method for synthesizing caulerpin | UNIV SHANGHAI MARITIME | 2014-09-03 | — | — | CN | claimed |
| CN-101085778-B | Preparation method for etodolac | SHANDONG XINHUA PHARMACEUTICAL | 2010-05-19 | — | — | CN | claimed |
| CN-101085778-A | Preparation method for etodolac | SHANDONG XINHUA PHARMACEUTICAL (CN) | 2007-12-12 | — | — | CN | claimed |
| CN-104016989-A | Method for synthesizing caulerpin | UNIV SHANGHAI MARITIME | 2014-09-03 | — | — | CN | disclosed |
| CN-101077872-B | Method for preparing etodolac methyl ester | SHANDONG XINHUA PHARMACEUTICAL | 2012-01-11 | — | — | CN | disclosed |
| CN-101085778-B | Preparation method for etodolac | SHANDONG XINHUA PHARMACEUTICAL | 2010-05-19 | — | — | CN | disclosed |
| CN-100577167-C | Pyridazino [4 | SANOFI AVENTIS | 2010-01-06 | — | — | CN | disclosed |
| CN-100497342-C | Preparation process of 1,8-disubstituent-1,3,4,9-tetrahydropyran (3,4-b)-indolyl-1-acetate | HANGZHOU KEBEN CHEMICAL CO LTD (CN) | 2009-06-10 | — | — | CN | disclosed |
| CN-101085778-A | Preparation method for etodolac | SHANDONG XINHUA PHARMACEUTICAL (CN) | 2007-12-12 | — | — | CN | disclosed |
| CN-101077872-A | Method for preparing etodolac methyl ester | SHANDONG XINHUA PHARMACEUTICAL (CN) | 2007-11-28 | — | — | CN | disclosed |
| CN-1740174-A | Prepn process of 1,8-disubstituent-1,3,4,9-tetrahydropyran (3,4-b)-indolyl-1-acetate | HANGZHOU KEBEN CHEMICAL CO LTD (CN) | 2006-03-01 | — | — | CN | disclosed |
| CN-1134440-C | 4-oxo-3,5-dihydro-4H-pyridazino [4,5-b]-indole-1-acetamide derivatives, their prepn. and their application in therapy | �����ʩ���عɷݹ�˾ | 2004-01-14 | — | — | CN | disclosed |
| CN-1355804-A | Process for preparing 1, 8-disubstituted-1, 3,4, 9-tetrahydropyrano (3, 4-b) -indole-1-acetic acid esters in a solvent containing hydroxyl groups | RANBAXY LAB LTD (IN) | 2002-06-26 | — | — | CN | disclosed |
| CN-1344161-A | Use of pyridazino [4,5-i(b)]indole-1-acetamide derivatives for preparing medicines for treating disease related to dysfunction of peripheral benzodiazepin receptors | SANOFI SYNTHELABO (FR) | 2002-04-10 | — | — | CN | disclosed |
| CN-1265108-A | 4-oxo-3,5-dihydro-4H-pyridazino [4,5-b]-indole-1-acetamide derivatives, their prepn. and their application in therapy | SANOFI SYNTHELABO (FR) | 2000-08-30 | — | — | CN | disclosed |
| CN-1230948-A | Pyranoindole and carbazole COX-2 inhibitors | AMERICAN HOME PROD (US) | 1999-10-06 | — | — | CN | disclosed |