Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.60 |
| ▸ | CDK4 | P11802 | 4/20 | 0.58 |
| ▸ | CCND1 | P24385 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873205 | 0.91 | CDK4 (0.60) | MAPK1CDK4CCND1LMNAKMT2A | |
| SCHEMBL9324414 | 0.87 | LMNA (0.57) | MAPK1CDK4CCND1LMNAKMT2A | |
| SCHEMBL27452610 | 0.86 | CDK4 (0.59) | MAPK1CDK4CCND1LMNAKMT2A | |
| SCHEMBL31211624 | 0.85 | MAPK1 (0.55) | MAPK1CDK4CCND1LMNAKMT2A | |
| SCHEMBL3821123 | 0.85 | MAPK1 (0.55) | MAPK1CDK4CCND1LMNAKMT2A | |
| SCHEMBL27467119 | 0.84 | KMT2A (0.56) | MAPK1CDK4CCND1LMNAKMT2A | |
| SCHEMBL26620578 | 0.81 | MTNR1A (0.42) | MAPK1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29035969 | 0.81 | ALDH1A1 (0.44) | KMT2ANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6724557 | 0.81 | MTNR1A (0.46) | MAPK1ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL8943436 | 0.81 | CDK4 (0.53) | MAPK1CDK4CCND1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100482667-C | Method for preparing 5-bromine-6-fluoro-8-methyl-1-ethyl-1,3,4,9- tetrahydropyrane[3,4-e] indole-1-ethyl acetate | SHANGHAI HUAYI GROUP CO (CN) | 2009-04-29 | — | — | CN | claimed |
| CN-1803800-A | Method for preparing 5-bromine-6-fluoro-8-methyl-1-ethyl-1,3,4,9- tetrahydropyrane[3,4-e] indole-1-ethyl acetate | SHANGHAI HUAYI GROUP CO (CN) | 2006-07-19 | — | — | CN | claimed |
| CN-114615891-A | High-potency formulations based on 2- [ (2, 4-dichlorophenyl) methyl ] -4,4' -dimethyl-3-isoxazolidone and a pre-emergent herbicide | 拜耳公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-110461153-B | Efficacy enhancer composition for agricultural chemicals | 花王株式会社 | 2022-01-28 | — | — | CN | disclosed |
| CN-110461154-B | Efficacy enhancer composition for agricultural chemicals | 花王株式会社 | 2021-11-09 | — | — | CN | disclosed |
| CN-111132973-A | Substituted 3-heteroaryloxy-1H-pyrazoles and their salts and their use as herbicidal active substances | 拜耳作物科学股份公司 | 2020-05-08 | — | — | CN | disclosed |
| CN-110891941-A | Substituted 5- (hetero) arylpyrazolamides and their salts and their use as herbicidally active substances | 拜耳作物科学股份公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-100482667-C | Method for preparing 5-bromine-6-fluoro-8-methyl-1-ethyl-1,3,4,9- tetrahydropyrane[3,4-e] indole-1-ethyl acetate | SHANGHAI HUAYI GROUP CO (CN) | 2009-04-29 | — | — | CN | disclosed |
| CN-1803800-A | Method for preparing 5-bromine-6-fluoro-8-methyl-1-ethyl-1,3,4,9- tetrahydropyrane[3,4-e] indole-1-ethyl acetate | SHANGHAI HUAYI GROUP CO (CN) | 2006-07-19 | — | — | CN | disclosed |
| CN-1795174-A | Novel substituted 3-thioindoles | ASTRAZENECA AB (SE) | 2006-06-28 | — | — | CN | disclosed |
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |