Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2616321 | 0.80 | HSD17B10 (0.60) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL30041535 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL2817935 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL29868628 | 0.78 | MEN1 (0.45) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL2405526 | 0.78 | MEN1 (0.45) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL14136359 | 0.76 | KMT2A (0.50) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3171539 | 0.76 | ACHE (0.71) | MEN1KMT2AKDM4EACHESMN1; SMN2 | |
| SCHEMBL2405165 | 0.76 | ACHE (0.58) | ACHE | |
| SCHEMBL29868981 | 0.76 | ACHE (0.58) | ACHE | |
| SCHEMBL29868439 | 0.76 | ACHE (0.58) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730597-B1 | HETEROCYCLIC ESTERS OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PROD (US) | 2001-03-07 | — | — | EP | claimed |