Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.73 |
| ▸ | HTR1A | P08908 | 4/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | HTR1D | P28221 | 2/20 | 0.73 |
| ▸ | HTR1B | P28222 | 2/20 | 0.73 |
| ▸ | HTR2C | P28335 | 2/20 | 0.73 |
| ▸ | HTR7 | P34969 | 2/20 | 0.73 |
| ▸ | HTR6 | P50406 | 2/20 | 0.73 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.73 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 2/20 | 0.69 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873259 | 0.88 | HTR2A (0.73) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL8252894 | 0.86 | HTR2A (0.76) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| 5-Methoxytryptamine SCHEMBL29390103 | 0.84 | HTR1A (1.00) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL29375720 | 0.84 | CYP2D6 (1.00) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL15128313 | 0.84 | HTR2A (0.73) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL29736216 | 0.84 | HTR2A (0.73) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL676574 | 0.84 | CYP2D6 (1.00) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| 5-Methoxytryptamine SCHEMBL41982 | 0.84 | HTR1A (1.00) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL8120951 | 0.84 | HTR2A (0.73) | HTR2AHTR1ACYP2D6CYP1A2HTR1D | |
| SCHEMBL5431365 | 0.83 | GPR84 (1.00) | HTR2AHTR1ACYP2D6CYP1A2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808303-B1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0808303-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024582-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1996-08-15 | — | — | WO | disclosed |