Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | HTR1D | P28221 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868130 | 0.82 | ALDH1A1 (0.49) | — | |
| SCHEMBL7876520 | 0.76 | ALDH1A1 (0.42) | — | |
| SCHEMBL31575341 | 0.73 | CA2 (0.49) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL10203012 | 0.73 | CA2 (0.51) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL15211143 | 0.71 | CA2 (0.54) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL31575339 | 0.71 | CA2 (0.54) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL16428909 | 0.71 | CA2 (0.54) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL407496 | 0.71 | CA2 (0.54) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL15219843 | 0.70 | CA2 (0.52) | CA2HTR1AHTR1DSIGMAR1ADRA2A | |
| SCHEMBL15219505 | 0.70 | CA2 (0.52) | CA2HTR1AHTR1DSIGMAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |