1-Naphthol

1-Naphthol

SCHEMBL787347

C#N.Oc1cccc2ccccc12

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.85
PTPN22 Q9Y2R2 1/20 0.50
IDO1 P14902 1/20 0.50
KDM4E B2RXH2 2/20 0.48
PLAU P00749 1/20 0.48
MAPKAPK2 P49137 1/20 0.48
CTDSP1 Q9GZU7 1/20 0.48
NQO2 P16083 1/20 0.48
HSD17B10 Q99714 4/20 0.48
TDP1 Q9NUW8 3/20 0.48
TSHR P16473 2/20 0.48
MAPT P10636 2/20 0.48
HPGD P15428 2/20 0.48
ALOX15 P16050 2/20 0.48
RECQL P46063 2/20 0.48
APP P05067 1/20 0.48
THRB P10828 1/20 0.48
CASP1 P29466 1/20 0.48
SNCA P37840 1/20 0.48
POLB P06746 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Naphthol SCHEMBL273260 0.92 CYP1A2 (1.00) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL10486461 0.92 CYP1A2 (1.00) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL3416 0.92 CYP1A2 (1.00) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL29767730 0.92 CYP1A2 (1.00) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL11247168 0.90 CYP1A2 (0.94) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL8904232 0.90 CYP1A2 (0.94) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL11295882 0.90 CYP1A2 (0.94) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL21490911 0.90 CYP1A2 (0.94) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL8219136 0.90 CYP1A2 (0.94) CYP1A2PTPN22IDO1KDM4EPLAU
1-Naphthol SCHEMBL9850314 0.90 CYP1A2 (0.94) CYP1A2PTPN22IDO1KDM4EPLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1559006-A Methods and compositions for analyzing proteins 埃克来拉生物科学公司 2004-12-29 CN claimed
US-20240228500-A1 THERAPEUTIC CONJUGATES TOTUS MEDICINES INC. 2024-07-11 US disclosed
US-12029791-B2 Therapeutic conjugates TOTUS MEDICINES INC. (US) 2024-07-09 US disclosed
EP-4308121-A1 THERAPEUTIC CONJUGATES Totus Medicines Inc. (US) 2024-01-24 EP disclosed
US-20230405135-A1 THERAPEUTIC CONJUGATES TOTUS MEDICINES INC (US) 2023-12-21 US disclosed
EP-4210766-A1 THERAPEUTIC CONJUGATES Totus Medicines Inc. (US) 2023-07-19 EP disclosed
CN-110431123-B Laminated glass 积水化学工业株式会社 2023-04-18 CN disclosed
CN-110650929-B Laminated glass 积水化学工业株式会社 2023-04-07 CN disclosed
US-20230096658-A1 THERAPEUTIC CONJUGATES TOTUS MEDICINES INC. 2023-03-30 US disclosed
US-20220387603-A1 THERAPEUTIC CONJUGATES TOTUS MEDICINES INC. 2022-12-08 US disclosed
US-20200303044-A1 Devices and Methods for Authenticating a Medical Test and Use of the Same ESSENLIX CORPORATION (US) 2020-09-24 US disclosed
CN-110832852-A Photoelectric conversion element and adhesive JSR株式会社 2020-02-21 CN disclosed
CN-110650929-A Laminated glass 积水化学工业株式会社 2020-01-03 CN disclosed
WO-2019075415-A1 DEVICES AND METHODS FOR AUTHENTICATING A MEDICAL TEST AND USE OF THE SAME ESSENLIX CORPORATION (US) 2019-04-18 WO disclosed
US-20140255468-A1 MODIFIED POLYNUCLEOTIDES ENCODING PROGRAMMED CELL DEATH 1 MODERNA THERAPEUTICS, INC. (US) 2014-09-11 US disclosed
US-20120071353-A1 APPARATUS AND METHOD FOR PERFORMING NUCLEIC ACID ANALYSIS PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-22 US disclosed
CN-101116857-A Manufacturing method for thin film coating NIPPON OILS & FATS CO LTD (JP) 2008-02-06 CN disclosed
CN-1333388-C Optical disc, its recording method, its recording device, its reproducing method, and its reproducing device MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) 2007-08-22 CN disclosed
CN-1441637-A Compositions for repelling crawling insects BAYER AG (DE) 2003-09-10 CN disclosed
CN-1264485-A Optical disc, its recording method, its recording device, its reproducing method, and its reproducing device MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) 2000-08-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029791-B2 Therapeutic conjugates CD47, CD44, EPCAM CYP1A2 4587/4885PTPN22 887/4885IDO1 4317/4885
US-20240228500-A1 THERAPEUTIC CONJUGATES CD47, CD44, EPCAM CYP1A2 4587/4885PTPN22 887/4885IDO1 4317/4885
US-20220387603-A1 THERAPEUTIC CONJUGATES CD47, CD44, EPCAM CYP1A2 4587/4885PTPN22 887/4885IDO1 4317/4885
US-20230405135-A1 THERAPEUTIC CONJUGATES CD47, CD44, EPCAM CYP1A2 4587/4885PTPN22 887/4885IDO1 4317/4885
US-20140255468-A1 MODIFIED POLYNUCLEOTIDES ENCODING PROGRAMMED CELL DEATH 1 MSH2, POLRMT, PDCD1 CYP1A2 4863/4885PTPN22 1867/4885IDO1 2117/4885
US-20230096658-A1 THERAPEUTIC CONJUGATES CD47, CD44, EPCAM CYP1A2 4587/4885PTPN22 887/4885IDO1 4317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.